Redox-mediated activation of latent transforming growth factor-beta 1.
نویسندگان
چکیده
منابع مشابه
Mechanism of activation of latent recombinant transforming growth factor beta 1 by plasmin
Medium conditioned by Chinese hamster ovary (CHO) cells transfected with the simian pre-pro-TGF beta 1 cDNA contains high levels of latent TGF beta 1. The amino-terminal region of the TGF beta 1 precursor is secreted and can be detected in the conditioned medium by immunoblotting using peptide antibodies specific for amino-terminal peptides. Chemical cross-linking of CHO-conditioned medium usin...
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Transforming growth factor-betas (TGF-betas) are multifunctional cytokines that exist in 3 isoforms in mammals. The TGF-betas are ubiquitously expressed and all isoforms are secreted as biologically inactive precursors called latent TGF-beta (L-TGF-beta). L-TGF-betas are generally not effective molecules because they are unable to interact with their receptors. However, the removal of or confor...
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ژورنال
عنوان ژورنال: Molecular Endocrinology
سال: 1996
ISSN: 0888-8809,1944-9917
DOI: 10.1210/mend.10.9.8885242